1、產品物理參數:
|
常用名 |
PQ401 |
英文名 |
PQ 401 |
|
CAS號 |
196868-63-0 |
分子量 |
341.792 |
|
密度 |
1.4±0.1 g/cm3 |
沸點 |
426.1±45.0 °C at 760 mmHg |
|
分子式 |
C18H16ClN3O2 |
熔點 |
無資料 |
|
閃點 |
211.5±28.7 °C |
|
|
PQ401是IGF1R阻斷劑,能抑制IGF1R自磷酸化,IC50 < 1 uM。
|
描述 |
PQ401是IGF1R阻斷劑,能抑制IGF1R自磷酸化,IC50 < 1 uM。 |
|
相關類別 |
信號通路 >> 蛋白酪氨酸激酶 >> IGF-1R 研究領域 >> 癌癥 |
|
參考文獻 |
[1]. Gable KL, Maddux BA, Penaranda C, Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth. Mol Cancer Ther. 2006 Apr;5(4):1079-86. [2]. Troib A, Landau D, Youngren JF, The effects of type 1 IGF receptor inhibition in a mouse model of diabetic kidney disease. Growth Horm IGF Res. 2011 Oct;21(5):285-91. [3]. Sanchez-Alavez M, Osborn O, Tabarean IV, Insulin-like growth factor 1-mediated hyperthermia involves anterior hypothalamic insulin receptors. J Biol Chem. 2011 Apr 29;286(17):14983-90. [4]. Youssif C, et al. Myeloid p38α signaling promotes intestinal IGF-1 production and inflammation-associated tumorigenesis. EMBO Mol Med. 2018 Jul;10(7). pii: e8403. |
|
密度 |
1.4±0.1 g/cm3 |
|
沸點 |
426.1±45.0 °C at 760 mmHg |
|
分子式 |
C18H16ClN3O2 |
|
分子量 |
341.792 |
|
閃點 |
211.5±28.7 °C |
|
質量 |
341.093109 |
|
PSA |
63.25000 |
|
LogP |
5.35 |
|
外觀性狀 |
white |
|
蒸汽壓 |
0.0±1.0 mmHg at 25°C |
|
折射率 |
1.709 |
|
儲存條件 |
2-8°C |
|
水溶解性 |
DMSO: >10mg/mL |
|
1-(5-Chloro-2-methoxyphenyl)-3-(2-methyl-4-quinolinyl)urea |
|
IGF-1R Inhibitor II |
|
UNII-2N3LV83S8J |
|
1-(5-Chloro-2-methoxyphenyl)-3-(2-methylquinolin-4-yl)urea |
|
TCMDC-125497 |
|
N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl) |
|
Urea, N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)- |
|
PQ 401 |
|
PQ401 |